Johnson & Johnson
Job title:
Postdoctoral Fellow – API@MOF
Company
Johnson & Johnson
Job description
Postdoctoral Fellow – API@MOFAt Johnson & Johnson Technology, we solve big problems in healthcare every day. Working closely with colleagues across Johnson & Johnson, we elevate the digital savvy of the world’s largest healthcare company, innovate to create new digital solutions, and unlock the power of data and insights. We value the diverse backgrounds and perspectives of team members and collaborators who make our solutions stronger, and our workplace more inclusive.We are a place where builders, innovators, creators, and tinkerers join together to apply their talent for good. At the core of everything we do is our common commitment to improving health for humanity.With a reach of more than a billion people every day, there’s no limit to the impact you can make here. Are you ready to reimagine healthcare?Here, your career breakthroughs will change the future of health, in all the best ways. And you’ll change, too. You’ll be inspired, and you’ll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, cardiovascular and metabolic disorders, immunology, pulmonary hypertension, neuroscience, and infectious disease. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine, visit https:// https://www.jnj.com/innovative-medicine.
The J&J IM Discovery, Product Development, & Supply (DPDS) Postdoctoral Fellowship Program helps early career scientists gain the training and experience needed to further their careers while addressing the needs of global healthcare. Postdocs work side-by-side with DPDS scientists on innovative research projects and have the opportunity to present and publish their work. They also learn the functional role of scientists in the pharmaceutical industry and receive valuable career advice from mentors while building a network of professional contacts and developing the skills needed to advance their careers.This two-year Postdoc program will focus on the design, discovery, development, characterization, and performance assessment of known and/or novel pharmaceutically acceptable Metal-Organic Frameworks (MOFs) as drug delivery vehicles. The selected candidate will work in Chemical Process R&D (CPRD) to design robust, safe and scalable processes for neat and active pharmaceutical ingredient (API) loaded materials with the desired properties. This requires a strong cross-functional collaboration with Analytical Development (AD) for material characterization & stability testing, and Pharmaceutical Product Development & Supply (PPDS) for pharmaceutical characterization as well as performance testing to generate holistic understanding starting from the selection of the crystalline hybrid materials and their components, the associated solid form landscape, manufacturing process and storage conditions, and eventual API release performance of the in biopharmaceutical relevant media via in vitro dissolution and potentially generating proof of improved bioavailability in preclinical species. Additionally, the candidate will develop a thorough understanding of the intellectual property landscape of MOFs.As a Postdoc scientist, you will operate under limited supervision with a high level of autonomy to transform innovative ideas to concepts and practical solutions consistent with the project objectives. You will be tasked with drafting critical research questions, and with the ideation, design, planning and execution of experiments to address those. Activities in scope will include screening of raw materials and excipients, process development and scale-up, structural characterization and performance assessment to establish structure-property-performance relationships. On the job training will be provided by qualified staff. Additionally, you will be authoring reports and scientific publications and present data to the scientific community internally and externally. This position will require hands-on lab work, while offering ample scientific leadership and personal growth opportunities through training, mentoring and R&D-wide connectivity.Position Responsibilities (included but not limited to)
Discovery, synthesis and characterization of pharmaceutically accepted MOF as drug delivery vehicles
Process scale-up of the tailored MOFs
Development of loading protocols for the inclusion of preselected APIs on the target MOF materials
Application and performance assessment of the porous hosts in combination with the APIs
Development, training, conferences, internal meetings & symposiaA PhD degree in a scientific or technical field e.g. in Chemistry, Physics, Chemical Engineering, Bioscience Engineering, Pharmaceutical Sciences or closely related field.
Demonstrated competency and experience in organic synthesis, analytical chemistry, chemical thermodynamics, porous materials or reticular chemistry, and/or characterization with understanding of material properties.
Excellent knowledge of and hands-on experience with relevant analytical techniques for materials characterization (crystallinity, adsorption, stability), and performance evaluation.
Experience with small molecule crystallization and/or pharmaceutics is a clear be nefit.
Familiarity with computational chemistry for materials discovery is valued.Proven ability to transform innovative ideas into tangible concepts and practical solutions within the project timeline.
To make your ideas practical, you must possess a good amount of innovation and creativity and be able to think and act unconventionally.
Organizational, planning, problem-solving and scientific/technical leadership skills needed in the completion of the postdoc project deliverables, with a clear eye for safety in a lab-based setting.
Track record of scientific contributions, including peer reviewed publications and presentations, and/or patents.
Excellent oral and written communication skills and efficient information exchange in English.On-site presence (Beerse, Antwerp area, Belgium) and hands-on execution of lab activities.
Background in MOF synthesis and characterization
The successful candidate may be involved to a limited extent in external (e.g. CDMOs) and academic collaborations.For more than 130 years, diversity, equity & inclusion (DEI) have been part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Our commitment to respect the dignity and diversity of all is embedded in our Credo.
We know that the success of our business depends on having the best talent in a workforce that reflects the diverse markets we serve around the world and an inclusive culture that values different perspectives and life experiences
That is why we are working to create an inclusive environment where diverse backgrounds, perspectives and experiences are valued and each and every one of our people feels that they belong and can reach their potential. No matter who they are.
Diversity, Equity & Inclusion at Johnson & Johnson means “You Belong”!#JnJEMEAStudentCareers #JNJUndergraduate #JNJMasters #JNJFullTime
Expected salary
Location
Beerse, Antwerpen
Job date
Mon, 12 Aug 2024 22:57:37 GMT
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